Nfl Week 1 2025 Spreads. Tracking the nfl odds and betting lines for week 1 of the 2025 season with the best spreads, moneylines, and over/unders. All of the week 1 nfl lines are listed below, and sportsline's advanced computer model has all the nfl betting advice and nfl predictions you need to make the best week 1.
Compare nfl spreads, totals, and betting odds for december 02, 2025 from the best online sportsbooks. Here are the betting odds for week 1 of the 2025 nfl season, courtesy of fan duel’s nfl odds: